BDBM325561 1-Isopropyl-3-{5-[1-(3-methoxy propyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}-1H-indazole ::US9636335, 4
SMILES COCCCN1CCC(CC1)c1nnc(o1)-c1nn(C(C)C)c2ccccc12
InChI Key InChIKey=DWTFBJGTRBMHPG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 325561
Affinity DataEC50: 38nMAssay Description:A stable CHO cell line expressing recombinant human 5-HT4 receptor and pCRE-Luc reporter system was used for cell-based assay. The assay offers a non...More data for this Ligand-Target Pair
Affinity DataEC50: 44nMAssay Description:Partial agonist activity at human 5HT4E receptor expressed in CHO cells assessed as cAMP accumulation incubated for 4 hrs by luciferase reporter gene...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Suven Life Sciences
Curated by ChEMBL
Suven Life Sciences
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of hERG expressed in HEK293 cells at holding potential of -80 mV by whole cell patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 2 mins in presence of NADPH regenerating system by LC-MS/MS...More data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 12 mins in presence of NADPH regenerating system by ...More data for this Ligand-Target Pair
Affinity DataEC50: 185nMAssay Description:In vivo receptor occupancy in Wistar rat assessed as compound required for 50% 5HT4 receptor occupancy in brain administered orally measured after 1 ...More data for this Ligand-Target Pair
Affinity DataEC50: 59nMAssay Description:In vivo receptor occupancy in Wistar rat assessed as compound required for 50% 5HT4 receptor occupancy in plasma administered orally measured after 1...More data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Partial agonist activity at 5HT4A receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Partial agonist activity at 5HT4D receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Partial agonist activity at 5HT4E receptor (unknown origin)More data for this Ligand-Target Pair