BDBM32546 arylsulfonylpiperazine, 18

SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1

InChI Key InChIKey=SYQSWNRTYTVMSS-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 32546   

LigandPNGBDBM32546(arylsulfonylpiperazine, 18)
Affinity DataIC50: 13nM EC50:  547nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2009
Entry Details Article
PubMed
LigandPNGBDBM32546(arylsulfonylpiperazine, 18)
Affinity DataIC50: 11nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Shanghai Pharmaceutical Holding

Curated by ChEMBL
LigandPNGBDBM32546(arylsulfonylpiperazine, 18)
Affinity DataIC50: 11nMAssay Description:Inhibition of human 11beta HSD1 expressed in HEK293 cells assessed as assessed as inhibition of [1,2-(n)3H]cortisone to [3H]-cortisol after 60 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed