BDBM324631 1-[4-(oxetan-3- yl)piperazin-1-yl]-2-[4- [[8-[8-[3- (trifluoromethyl)azetidine- 1-carbonyl]-3,8- diazabicyclo[3.2.1]octan- 3-yl]-[1,2,4]triazolo[1,5-a] pyridin-2- yl]amino]pyrazol-1- yl]ethanone::US10189836, Example 194

SMILES FC(F)(F)C1CN(C1)C(=O)N1C2CCC1CN(C2)c1cccn2nc(Nc3cnn(CC(=O)N4CCN(CC4)C4COC4)c3)nc12

InChI Key InChIKey=WYCOGGXTVIONHM-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 324631   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM324631(1-[4-(oxetan-3- yl)piperazin-1-yl]-2-[4- [[8-[8-[3...)
Affinity DataKi:  0.400nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM324631(1-[4-(oxetan-3- yl)piperazin-1-yl]-2-[4- [[8-[8-[3...)
Affinity DataKi:  0.900nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent