BDBM324590 1-[3-[2-[[1-[2-(4- cyclohexylpiperazin-1-yl)- 2-oxo-ethyl]pyrazol-4- yl]amino]- [1,2,4]triazolo[1,5-a] pyridin-8-yl]-3,8- diazabicyclo[3.2.1]octan- 8-yl]-4,4,4-trifluoro-butan- 1-one::US10189836, Example 153

SMILES FC(F)(F)CCC(=O)N1C2CCC1CN(C2)c1cccn2nc(Nc3cnn(CC(=O)N4CCN(CC4)C4CCCCC4)c3)nc12

InChI Key InChIKey=YRJXEUXYEJCYHJ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 324590   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM324590(1-[3-[2-[[1-[2-(4- cyclohexylpiperazin-1-yl)- 2-ox...)
Affinity DataKi:  0.200nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM324590(1-[3-[2-[[1-[2-(4- cyclohexylpiperazin-1-yl)- 2-ox...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent