BDBM324527 1-(4-methylpiperazin-1- yl)-2-[4-[[8-[9-(thietane-3- carbonyl)-3,9- diazabicyclo[3.3.1]nonan- 3-yl]-[1,2,4]triazolo[1,5-a] pyridin-2- yl]amino]pyrazol-1- yl]ethanone::US10189836, Example 96

SMILES CN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CC3CCCC(C2)N3C(=O)C2CSC2)cn1

InChI Key InChIKey=XOAPNWGMXNSNKM-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 324527   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM324527(1-(4-methylpiperazin-1- yl)-2-[4-[[8-[9-(thietane-...)
Affinity DataKi:  0.400nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM324527(1-(4-methylpiperazin-1- yl)-2-[4-[[8-[9-(thietane-...)
Affinity DataKi:  0.5nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent