BDBM324489 1-[4-[methyl(oxetan-3- yl)amino]-1-piperidyl]-2- [4-[[8-[8-[3- (trifluoromethyl)azetidine- 1-carbonyl]-3,8- diazabicyclo[3.2.1]octan- 3-yl]-[1,2,4]triazolo[1,5-a] pyridin-2- yl]amino]pyrazol-1- yl]ethanone::US10189836, Example 62

SMILES CN(C1COC1)C1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CC3CCC(C2)N3C(=O)N2CC(C2)C(F)(F)F)cn1

InChI Key InChIKey=QCNDTYOUSCWVBC-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 324489   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM324489(1-[4-[methyl(oxetan-3- yl)amino]-1-piperidyl]-2- [...)
Affinity DataKi:  0.5nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM324489(1-[4-[methyl(oxetan-3- yl)amino]-1-piperidyl]-2- [...)
Affinity DataKi:  0.700nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
Go to US Patent