BDBM324299 (R)-5-(tert-butyl)-N-(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[c]pyridin-9-yl)-1,2,4-oxadiazole-3-carboxamide::US10189829, Compound 42a::US10227341, Compound 42a::US10961237, Compound 42a::US11858926, Compound 42a

SMILES Cn1cc(Nc2nccc(n2)-c2cc3CCCC[C@@H](NC(=O)c4noc(n4)C(C)(C)C)c3cn2)cn1

InChI Key InChIKey=YTOLZAYZMLCFQG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 324299   

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324299((R)-5-(tert-butyl)-N-(3-(2-((1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324299((R)-5-(tert-butyl)-N-(3-(2-((1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 505nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324299((R)-5-(tert-butyl)-N-(3-(2-((1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [14-552](Human)
Biogen Ma

US Patent
LigandPNGBDBM324299((R)-5-(tert-butyl)-N-(3-(2-((1-methyl-1H-pyrazol-4...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
Go to US Patent