BDBM323437 3-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-Amine::US10188615, Example 1::US10639286, Example 1

SMILES NCCCc1cccc(OCC2CCCCC2)c1

InChI Key InChIKey=IPQJGLPIYPNWKY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 323437   

TargetRetinoid isomerohydrolase(Human)
Acucela

US Patent
LigandPNGBDBM323437(3-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-Amine | US...)
Affinity DataIC50: 55nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetRetinoid isomerohydrolase(Bovine)
Acucela

US Patent
LigandPNGBDBM323437(3-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-Amine | US...)
Affinity DataIC50: 1.00E+3nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J. Biol. Chem. 274:8577-85 (1999); see also Golczak et al., P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
Go to US Patent

TargetRetinaldehyde-binding protein 1(Human)
Acucela

US Patent
LigandPNGBDBM323437(3-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-Amine | US...)
Affinity DataIC50: 55nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J Biol. Chem. 274:8577-85 (1999).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2021
Entry Details
Go to US Patent

TargetRetinaldehyde-binding protein 1(Bovine)
Acucela

US Patent
LigandPNGBDBM323437(3-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-Amine | US...)
Affinity DataIC50: 100nMAssay Description:Isomerase inhibition reactions were performed essentially as described (Stecher et al., J Biol. Chem. 274:8577-85 (1999).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2021
Entry Details
Go to US Patent

TargetRetinoid isomerohydrolase(Bovine)
Acucela

US Patent
LigandPNGBDBM323437(3-(3-(Cyclohexylmethoxy)Phenyl)Propan-1-Amine | US...)
Affinity DataIC50: 1.55E+3nMAssay Description:Inhibition of RPE65 in bovine microsomes assessed as reduction on 11-cis-retinol production incubated for 1 hr by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed