BDBM32325 1-(3-chlorophenyl)-3-(2-pyridin-3-ylpyrimidin-4-yl)urea::1-(3-chlorophenyl)-3-[2-(3-pyridinyl)-4-pyrimidinyl]urea::1-(3-chlorophenyl)-3-[2-(3-pyridyl)pyrimidin-4-yl]urea::MLS000763594::N-(3-chlorophenyl)-N'-[2-(3-pyridinyl)-4-pyrimidinyl]urea::SMR000337179::cid_1488502

SMILES Clc1cccc(NC(=O)Nc2ccnc(n2)-c2cccnc2)c1

InChI Key InChIKey=GTZVHFRMLFQDFR-UHFFFAOYSA-N

Data  5 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 32325   

LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataEC50:  1.14E+3nMpH: 7.4 T: 2°CAssay Description:The HTS assay was conducted in 384-well microplates in a total assay volume per well of 10.1 microliters (5 microliters of bead mixture, 0.1 microlit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataEC50:  2.02E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataEC50:  1.11E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetBcl-2-like protein 2(Human)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataEC50:  1.59E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetSignal transducer and activator of transcription 3 [702-738,740-752](Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataIC50: 3.20E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetSignal transducer and activator of transcription 1-alpha/beta(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataIC50: 5.57E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataEC50:  499nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2011
Entry Details
PCBioAssay
TargetDNA damage-inducible transcript 3 protein(Mouse)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
PCBioAssay
TargetGlycogen synthase kinase-3 beta(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2011
Entry Details
PCBioAssay
TargetDNA damage-inducible transcript 3 protein(Mouse)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay
TargetX-box-binding protein 1(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32325(SMR000337179 | 1-(3-chlorophenyl)-3-(2-pyridin-3-y...)
Affinity DataIC50: 2.44E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Dr. Randal Kaufman, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay