BDBM323089 N-(5-chlorothiazol-2-yl)-4-(trans-4-(3,4-difluorophenyl)piperidin-3-yl)methoxy)-2,5-difluorobenzenesulfonamide::US9630929, Example 61

SMILES Fc1ccc(cc1F)C1CCNC[C@H]1COc1cc(F)c(cc1F)S(=O)(=O)Nc1ncc(Cl)s1

InChI Key InChIKey=VHKPEJOGTWZSOP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 323089   

TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM323089(N-(5-chlorothiazol-2-yl)-4-(trans-4-(3,4-difluorop...)
Affinity DataIC50: 100nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM323089(N-(5-chlorothiazol-2-yl)-4-(trans-4-(3,4-difluorop...)
Affinity DataIC50: 21.6nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM323089(N-(5-chlorothiazol-2-yl)-4-(trans-4-(3,4-difluorop...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM323089(N-(5-chlorothiazol-2-yl)-4-(trans-4-(3,4-difluorop...)
Affinity DataIC50: 1.00E+4nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
Go to US Patent