BDBM323018 1-Methyl-4-[({(1R,2R)-2-[4-(3-methyl-1H- pyrazol-5- yl)benzoyl]cyclohexyl}carbonyl)amino]- 1H-pyrazole-5-carboxamide::US10183947, Example 3::US10508119, Example 3::US11001589, Example 3::US11691978, Example 3

SMILES Cc1cc([nH]n1)-c1ccc(cc1)C(=O)[C@@H]1CCCC[C@H]1C(=O)Nc1cnn(C)c1C(N)=O

InChI Key InChIKey=QOHSQTYLLPTMPP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 323018   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM323018(US10183947, Example 3 | 1-Methyl-4-[({(1R,2R)-2-[4...)
Affinity DataIC50: 37nMAssay Description:Compounds were tested in a competition binding assay using 3H-MK591 as tracer. (Preparation of MK-591 is described in Bioorg. Med. Chem. Lett. 1999, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Astrazeneca

US Patent
LigandPNGBDBM323018(US10183947, Example 3 | 1-Methyl-4-[({(1R,2R)-2-[4...)
Affinity DataIC50: 35nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed