BDBM322721 2-(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[4,5-d]pyridazin-4-yl) amino)phenyl)cyclohexyl)acetic acid::US10183944, Example 91

SMILES OC(=O)CC1CCC(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1

InChI Key InChIKey=OILJTSQUFHFIEV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322721   

TargetTyrosine-protein kinase SYK(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322721(2-(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Affinity DataIC50: 10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322721(2-(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Affinity DataIC50: 50nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent