BDBM322643 1-(4-(5-oxo-2-phenyl-5,6- dihydropyrimido[4,5-d]pyridazin-4- ylamino)phenyl)piperidine-4- carboxylic acid::US10183944, Example 13::US10647720, Ex. # 13

SMILES OC(=O)C1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)-c2ccccc2)cc1

InChI Key InChIKey=OYUFXKRLOSEYCM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 322643   

TargetTyrosine-protein kinase SYK(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322643(1-(4-(5-oxo-2-phenyl-5,6- dihydropyrimido[4,5-d]py...)
Affinity DataIC50: 50nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322643(1-(4-(5-oxo-2-phenyl-5,6- dihydropyrimido[4,5-d]py...)
Affinity DataIC50: 10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322643(1-(4-(5-oxo-2-phenyl-5,6- dihydropyrimido[4,5-d]py...)
Affinity DataIC50: 30nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322643(1-(4-(5-oxo-2-phenyl-5,6- dihydropyrimido[4,5-d]py...)
Affinity DataIC50: 10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
Go to US Patent