BDBM322187 3-(4-((1H-indazol-5-yl)amino)pyrimidin-2-yl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)benzamide TFA salt::US10183931, Example 20::US10696660, Example 20::US11311541, Example 20

SMILES O=C(NC1CCS(=O)(=O)CC1)c1cccc(c1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1

InChI Key InChIKey=LOOOQQWLLSKLGA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 322187   

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322187(US10183931, Example 20 | 3-(4-((1H-indazol-5-yl)am...)
Affinity DataIC50: 400nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM322187(US10183931, Example 20 | 3-(4-((1H-indazol-5-yl)am...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322187(US10183931, Example 20 | 3-(4-((1H-indazol-5-yl)am...)
Affinity DataIC50: 400nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322187(US10183931, Example 20 | 3-(4-((1H-indazol-5-yl)am...)
Affinity DataIC50: 1.00E+4nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322187(US10183931, Example 20 | 3-(4-((1H-indazol-5-yl)am...)
Affinity DataIC50: 400nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM322187(US10183931, Example 20 | 3-(4-((1H-indazol-5-yl)am...)
Affinity DataIC50: 1.00E+4nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent