BDBM322170 US10183931, Example 171::US10696660, Example 171::US11311541, Example 171

SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C)-c1cccc(OCC(=O)NC2CC2)c1

InChI Key InChIKey=CSXLIEXWFOURBC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 322170   

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322170(US10183931, Example 171 | US10696660, Example 171 ...)
Affinity DataIC50: 80nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM322170(US10183931, Example 171 | US10696660, Example 171 ...)
Affinity DataIC50: 7.50E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Millipore immuno-based 96 well plate assay (Millipore catalog number CSA001). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322170(US10183931, Example 171 | US10696660, Example 171 ...)
Affinity DataIC50: 80nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322170(US10183931, Example 171 | US10696660, Example 171 ...)
Affinity DataIC50: 7.50E+3nMAssay Description:Purified active ROCK1 and ROCK2 were obtained from Invitrogen (catalog numbers ROCK1, PV3691 and ROCK2, PV3759). The kit components include a coumari...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Kadmon

US Patent
LigandPNGBDBM322170(US10183931, Example 171 | US10696660, Example 171 ...)
Affinity DataIC50: 80nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Kadmon

US Patent
LigandPNGBDBM322170(US10183931, Example 171 | US10696660, Example 171 ...)
Affinity DataIC50: 7.50E+3nMAssay Description:Dose response curves for Rho-kinase inhibition were derived from a Invitrogen Z′-LYTE Kinase Assay Kit (Invitrogen catalog number PV3793). Puri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent