BDBM322044 (E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)methyl)phenyl)-1-(4-((5-methoxypyridin-2-yl)methyl)piperazin-1-yl)prop-2-en-1-one::US10183025, Example 140.1::US9763957, Example 140.1

SMILES COc1ccc(CN2CCN(CC2)C(=O)\C=C\c2ccc(Cl)cc2Cn2nnc(C)n2)nc1

InChI Key InChIKey=JQTRFEYTVDZWMO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 322044   

TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM322044(US10183025, Example 140.1 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 5.90nMAssay Description:Reagents LPC (oleoyl (18:1)) was purchased from Avanti Polar Lipids (Alabaster, Ala.) and solubilized in methanol to 20 mM. Amplex Red was obtained f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM322044(US10183025, Example 140.1 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 5.90nMAssay Description:Method All experimental measurements were performed in black 384 well polystyrene (low volume, round bottom, Corning (3676)) plates. PerkinElmer EnVi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM322044(US10183025, Example 140.1 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM322044(US10183025, Example 140.1 | (E)-3-(4-Chloro-2-((5-...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed