BDBM322027 (R,E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)methyl)phenyl)-1-(4-((5-methoxypyridin-2-yl)methyl)-2-methylpiperazin-1-yl)prop-2-en-1-one::US10183025, Example 123::US9763957, Example 123

SMILES COc1ccc(CN2CCN([C@H](C)C2)C(=O)\C=C\c2ccc(Cl)cc2Cn2nnc(C)n2)nc1

InChI Key InChIKey=BCFMHSXCNXYVOF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322027   

TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM322027((R,E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)me...)
Affinity DataIC50: 3.5nMAssay Description:Reagents LPC (oleoyl (18:1)) was purchased from Avanti Polar Lipids (Alabaster, Ala.) and solubilized in methanol to 20 mM. Amplex Red was obtained f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
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TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM322027((R,E)-3-(4-Chloro-2-((5-methyl-2H-tetrazol-2-yl)me...)
Affinity DataIC50: 3.5nMAssay Description:Method All experimental measurements were performed in black 384 well polystyrene (low volume, round bottom, Corning (3676)) plates. PerkinElmer EnVi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
Go to US Patent