BDBM321948 (E)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-1-yl)-3-(2-((5-methyl-2H-tetrazol-2-yl)methyl)-4-(trifluoromethyl)phenyl)prop-2-en-1-one::US10183025, Example 57::US9763957, Example 57

SMILES Cc1nnn(Cc2cc(ccc2\C=C\C(=O)N2CCC(CC2)c2nnc(C)o2)C(F)(F)F)n1

InChI Key InChIKey=YFDNXWTWDPWCOC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 321948   

TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM321948((E)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-...)
Affinity DataIC50: 8nMAssay Description:Reagents LPC (oleoyl (18:1)) was purchased from Avanti Polar Lipids (Alabaster, Ala.) and solubilized in methanol to 20 mM. Amplex Red was obtained f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM321948((E)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-...)
Affinity DataIC50: 8nMAssay Description:Method All experimental measurements were performed in black 384 well polystyrene (low volume, round bottom, Corning (3676)) plates. PerkinElmer EnVi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM321948((E)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ATX in human serum assessed as reduction in LPA (18:1) level by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM321948((E)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by automated Qpatch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetAutotaxin(Human)
Novartis

US Patent
LigandPNGBDBM321948((E)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)piperidin-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant ATX expressed in HEK293 cells assessed as inhibition of choline release using LPC (18:1) as substrate preincubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed