BDBM321516 US10183021, Compound I-454

SMILES OC(=O)[C@H]1[C@H](CCCN1c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)C(F)(F)F

InChI Key InChIKey=HMTHMPQCAXCCGZ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321516   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Ironwood Pharmaceuticals

US Patent
LigandPNGBDBM321516(US10183021, Compound I-454)
Affinity DataEC50: <100nMAssay Description:Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent