BDBM321468 6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzimidazol-4-yl]-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 60

SMILES C=CCCn1cc(-c2cc(cc3[nH]cnc23)C(=O)N2CCOCC2)c2cc[nH]c2c1=O

InChI Key InChIKey=RLNJZBANHSVNDS-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 321468   

TargetChromatin remodeling regulator CECR2 [424-538](Human)
Genentech

US Patent
LigandPNGBDBM321468(6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzi...)
Affinity DataIC50: 12nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321468(6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzi...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM321468(6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzi...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM321468(6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzi...)
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321468(6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzi...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321468(6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzi...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM321468(6-but-3-enyl-4-[6-(morpholine-4-carbonyl)-1H-benzi...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant His-tagged BRD9 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed