BDBM321144 US10174049, Example 11::US10385066, Example 11::US9738658, Example 11::US9796729, 11

SMILES Nc1ncnc2OCCN(c3cnc4n(ccc4c3)-c3cc(Cl)cc(Cl)c3)C(=O)c12

InChI Key InChIKey=JXUQBFRKFDMPMV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 321144   

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321144(US10174049, Example 11 | US9738658, Example 11 | U...)
Affinity DataIC50: 13.3nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321144(US10174049, Example 11 | US9738658, Example 11 | U...)
Affinity DataIC50: 13.3nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321144(US10174049, Example 11 | US9738658, Example 11 | U...)
Affinity DataIC50: 13.3nMAssay Description:For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetDiacylglycerol O-acyltransferase 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM321144(US10174049, Example 11 | US9738658, Example 11 | U...)
Affinity DataIC50: 13.3nMAssay Description:LE assay: For inhibition of triacylglycerol product formation, 11 uL, reactions were nm in white Polyplate-384 (PerkinElmer6007300) starting with a 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent