BDBM321055 US10174040, Example 139::US9963456, Example 139::[(2R,3S,5R)-5-[4-Amino-5-[2-(o-tolyl)thiazol-4-yl]pyrrolo[2,3-d]pyrimidin-7-yl]-3-hydroxy-tetrahydrofuran-2-yl]methyl sulfamate

SMILES Cc1ccccc1-c1nc(cs1)-c1cn([C@H]2C[C@H](O)[C@@H](COS(N)(=O)=O)O2)c2ncnc(N)c12

InChI Key InChIKey=OSQDPPMQCZYHHS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 321055   

TargetNEDD8-conjugating enzyme UBE2F(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321055(US10174040, Example 139 | [(2R,3S,5R)-5-[4-Amino-5...)
Affinity DataIC50: 17nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetCarbonic anhydrase 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321055(US10174040, Example 139 | [(2R,3S,5R)-5-[4-Amino-5...)
Affinity DataIC50: 410nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetCarbonic anhydrase 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321055(US10174040, Example 139 | [(2R,3S,5R)-5-[4-Amino-5...)
Affinity DataIC50: 410nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent