BDBM321000 8-[2-[4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoylamino)methyl]tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidin-5-yl]ethynyl]-7-fluoro-4-methyl-2,3-dihydro-1,4-benzoxazine::US10174040, Example 64::US9963456, Example 64

SMILES CN1CCOc2c1ccc(F)c2C#Cc1cn([C@@H]2O[C@H](CNS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12

InChI Key InChIKey=MQXXNVWXDNYFCB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 321000   

TargetNEDD8-conjugating enzyme UBE2F(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321000(8-[2-[4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(s...)
Affinity DataIC50: 9.40nMAssay Description:A purified NAE (heterodimer of APPBP1 and UBA3) solution was prepared in the following manner. The human APPBP1 gene (NCBI Reference Sequence number:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
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TargetCarbonic anhydrase 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321000(8-[2-[4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(s...)
Affinity DataIC50: 1.00E+3nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetCarbonic anhydrase 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM321000(8-[2-[4-Amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(s...)
Affinity DataIC50: 1.00E+3nMAssay Description:The carbonic anhydrase II enzyme activity inhibition was measured by measuring the esterase activity in which carbonic anhydrase II degrades 4-nitrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2020
Entry Details
Go to US Patent