BDBM320688 (R)- or (S)-1-(Cyclopropyl(3-fluoro- 4-(2,2,2- trifluoroethyl)phenyl)methyl)-6- (dimethylamino)-3-(hydroxymethyl)- 1H-pyrazolo[3,4-d]pyrimidin-4(5H)- one::US10174037, Example 94::US10174037, Example 95

SMILES CN(C)c1nc2n(nc(CO)c2c(=O)[nH]1)C(C1CC1)c1ccc(CC(F)(F)F)c(F)c1

InChI Key InChIKey=LGHIMSZFZOFXRW-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320688   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320688((R)- or (S)-1-(Cyclopropyl(3-fluoro- 4-(2,2,2- tri...)
Affinity DataKi:  0.140nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320688((R)- or (S)-1-(Cyclopropyl(3-fluoro- 4-(2,2,2- tri...)
Affinity DataKi:  0.150nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320688((R)- or (S)-1-(Cyclopropyl(3-fluoro- 4-(2,2,2- tri...)
Affinity DataKi:  0.390nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320688((R)- or (S)-1-(Cyclopropyl(3-fluoro- 4-(2,2,2- tri...)
Affinity DataKi:  0.440nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent