BDBM320684 (R)- or (S)-1-(1-(4- (Difluoromethyl)phenyl)-2- methylpropyl)-6-(dimethylamino)-3- (hydroxymethyl)-1H-pyrazolo[3,4- d]pyrimidin-4(5H)-one::US10174037, Example 90::US10174037, Example 91

SMILES CC(C)C(c1ccc(cc1)C(F)F)n1nc(CO)c2c1nc([nH]c2=O)N(C)C

InChI Key InChIKey=UPVMMNYVAIPETO-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320684   

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320684(US10174037, Example 91 | (R)- or (S)-1-(1-(4- (Dif...)
Affinity DataKi:  0.180nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320684(US10174037, Example 91 | (R)- or (S)-1-(1-(4- (Dif...)
Affinity DataKi:  0.180nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320684(US10174037, Example 91 | (R)- or (S)-1-(1-(4- (Dif...)
Affinity DataKi:  1.10nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320684(US10174037, Example 91 | (R)- or (S)-1-(1-(4- (Dif...)
Affinity DataKi:  2.30nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent