BDBM320519 US10174035, Compound 65::{4-[cis-2,6-Dimethylmorpholin-4-yl]piperidin-1-yl}[6-(morpholin-4-yl)-2-(1H-pyrazol-4-yl)-9H-purin-8-yl]methanone

SMILES C[C@H]1CN(C[C@@H](C)O1)C1CCN(CC1)C(=O)c1nc2c(nc(nc2[nH]1)-c1cn[nH]c1)N1CCOCC1

InChI Key InChIKey=JDOYGHGNDCHQPK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 320519   

LigandPNGBDBM320519(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Affinity DataIC50: 12nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM320519(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Affinity DataIC50: 12nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM320519(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Affinity DataIC50: 986nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM320519(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Affinity DataIC50: 9.77E+3nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM320519(US10174035, Compound 65 | {4-[cis-2,6-Dimethylmorp...)
Affinity DataIC50: 1.00E+4nMAssay Description:The Kinase-Glo luminescent kinase assay kit (from Promega) was used to measure kinase activity. In this assay, amount of ATP remaining in solution fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent