BDBM320463 4-(6-(4-(2-(2- fluorophenyl)-2- hydroxyacetyl)piper- azin-1-yl)pyridin-3-yl)- 6-(1-methyl-1H- pyrazol-4- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US10174028, Example 10

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)C(O)Cc2cccc(F)c2)c2c(cnn2c1)C#N

InChI Key InChIKey=JKZIQZOUJBLOMD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 320463   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM320463(4-(6-(4-(2-(2- fluorophenyl)-2- hydroxyacetyl)pipe...)
Affinity DataIC50: 4.5nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent