BDBM320166 3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 333

SMILES C[C@@H](NC(=O)c1cc(OC[C@@]2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F

InChI Key InChIKey=FUZHKJYNGBDBHI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 320166   

TargetP2X purinoceptor 3(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320166(US10174016, Example 333 | 3-[(3-methyltetrahydrofu...)
Affinity DataIC50: 4nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
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Date in BDB:
5/15/2019
Entry Details
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TargetP2X purinoceptor 2(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320166(US10174016, Example 333 | 3-[(3-methyltetrahydrofu...)
Affinity DataIC50: 122nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetCytochrome P450 1A2(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320166(US10174016, Example 333 | 3-[(3-methyltetrahydrofu...)
Affinity DataIC50: 2.00E+4nMAssay Description:Use of in vitro assays to evaluate the inhibition potential of new drug candidates towards CYP-mediated metabolism has been shown to be effective as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetCytochrome P450 2C8(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320166(US10174016, Example 333 | 3-[(3-methyltetrahydrofu...)
Affinity DataIC50: 2.00E+4nMAssay Description:Use of in vitro assays to evaluate the inhibition potential of new drug candidates towards CYP-mediated metabolism has been shown to be effective as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetCytochrome P450 2C9(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320166(US10174016, Example 333 | 3-[(3-methyltetrahydrofu...)
Affinity DataIC50: 1.98E+4nMAssay Description:Use of in vitro assays to evaluate the inhibition potential of new drug candidates towards CYP-mediated metabolism has been shown to be effective as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetCytochrome P450 2D6(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320166(US10174016, Example 333 | 3-[(3-methyltetrahydrofu...)
Affinity DataIC50: 2.00E+4nMAssay Description:Use of in vitro assays to evaluate the inhibition potential of new drug candidates towards CYP-mediated metabolism has been shown to be effective as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetCytochrome P450 3A4(Human)
Beyer Aktiengesellschaft

US Patent
LigandPNGBDBM320166(US10174016, Example 333 | 3-[(3-methyltetrahydrofu...)
Affinity DataIC50: 2.00E+4nMAssay Description:Use of in vitro assays to evaluate the inhibition potential of new drug candidates towards CYP-mediated metabolism has been shown to be effective as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent