BDBM31984 Dipeptidyl nitrile inhibitor, 17

SMILES Cc1ccc2cc(C)cc(C(=O)N[C@@H](Cc3cccc(Cl)c3)C(=O)NCC#N)c2c1

InChI Key InChIKey=BFTVAARJISBTAJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31984   

TargetProcathepsin L [114-333,T223A](Human)
Astrazeneca

LigandPNGBDBM31984(Dipeptidyl nitrile inhibitor, 17)
Affinity DataIC50: 20nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

LigandPNGBDBM31984(Dipeptidyl nitrile inhibitor, 17)
Affinity DataIC50: 1.00E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Astrazeneca

LigandPNGBDBM31984(Dipeptidyl nitrile inhibitor, 17)
Affinity DataIC50: 1.00E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Astrazeneca

LigandPNGBDBM31984(Dipeptidyl nitrile inhibitor, 17)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Astrazeneca

LigandPNGBDBM31984(Dipeptidyl nitrile inhibitor, 17)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed