BDBM31975 Dipeptidyl nitrile inhibitor, 8

SMILES Cc1cccc(c1)C(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)NCC#N

InChI Key InChIKey=RNABZOAFYBXFAJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31975   

TargetProcathepsin L [114-333,T223A](Human)
Astrazeneca

LigandPNGBDBM31975(Dipeptidyl nitrile inhibitor, 8)
Affinity DataIC50: 251nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin L2(Human)
Astrazeneca

LigandPNGBDBM31975(Dipeptidyl nitrile inhibitor, 8)
Affinity DataIC50: 794nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin S(Human)
Astrazeneca

LigandPNGBDBM31975(Dipeptidyl nitrile inhibitor, 8)
Affinity DataIC50: 398nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Astrazeneca

LigandPNGBDBM31975(Dipeptidyl nitrile inhibitor, 8)
Affinity DataIC50: 6.31E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Astrazeneca

LigandPNGBDBM31975(Dipeptidyl nitrile inhibitor, 8)
Affinity DataIC50: 5.01E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details Article
PubMed