BDBM319699 3-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)butyl)-1H-indole-5-carbonitrile::US10174011, Example 70

SMILES N#Cc1ccc2[nH]cc(CCCCN3CCN(CC3)c3cccc4sccc34)c2c1

InChI Key InChIKey=AJCBTMQLMBVUBO-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 319699   

Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319699(US10174011, Example 70 | 3-(4-(4-(benzo[b]thiophen...)
Affinity DataEC50:  9.70nMAssay Description:The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319699(US10174011, Example 70 | 3-(4-(4-(benzo[b]thiophen...)
Affinity DataIC50: 79.7nMAssay Description:The D2 receptor antagonism activity test (The antagonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319699(US10174011, Example 70 | 3-(4-(4-(benzo[b]thiophen...)
Affinity DataIC50: 332nMAssay Description:The 5-HT2A receptor antagonism activity test (The antagonism activity of test compounds on 5-HT2A receptor expressing human recombinant 5-HT2A recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent