BDBM319634 3-(2-(4-(benzo[b]thiophen-4-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one::US10174011, Example 36

SMILES Cc1nc2C(O)CCCn2c(=O)c1CCN1CCC(CC1)c1cccc2sccc12

InChI Key InChIKey=YYHRMWYQOMFFHW-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 319634   

Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319634(US10174011, Example 36 | 3-(2-(4-(benzo[b]thiophen...)
Affinity DataEC50:  34.1nMAssay Description:The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319634(US10174011, Example 36 | 3-(2-(4-(benzo[b]thiophen...)
Affinity DataIC50: 75.4nMAssay Description:The D2 receptor antagonism activity test (The antagonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319634(US10174011, Example 36 | 3-(2-(4-(benzo[b]thiophen...)
Affinity DataIC50: 7.66nMAssay Description:The 5-HT2A receptor antagonism activity test (The antagonism activity of test compounds on 5-HT2A receptor expressing human recombinant 5-HT2A recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319634(US10174011, Example 36 | 3-(2-(4-(benzo[b]thiophen...)
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319634(US10174011, Example 36 | 3-(2-(4-(benzo[b]thiophen...)
Affinity DataEC50:  34nMAssay Description:Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319634(US10174011, Example 36 | 3-(2-(4-(benzo[b]thiophen...)
Affinity DataIC50: 75nMAssay Description:Antagonist activity at dopamine D2 receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed