BDBM319633 2-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)quinazolin-4(3H)-one::US10174011, Example 35

SMILES O=c1[nH]c(CCN2CCN(CC2)c2cccc3sccc23)nc2ccccc12

InChI Key InChIKey=MZWXQBFYLBCQDO-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 319633   

Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 319633BDBM319633(US10174011, Example 35 | 2-(2-(4-(benzo[b]thiophen...)
Affinity DataIC50: 21.5nMAssay Description:The 5-HT2A receptor antagonism activity test (The antagonism activity of test compounds on 5-HT2A receptor expressing human recombinant 5-HT2A recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 319633BDBM319633(US10174011, Example 35 | 2-(2-(4-(benzo[b]thiophen...)
Affinity DataEC50:  41.9nMAssay Description:The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 319633BDBM319633(US10174011, Example 35 | 2-(2-(4-(benzo[b]thiophen...)
Affinity DataIC50: 216nMAssay Description:The D2 receptor antagonism activity test (The antagonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent