BDBM319609 3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one::US10174011, Example 4

SMILES Cc1nc2C(O)CCCn2c(=O)c1CCN1CCN(CC1)c1cccc2sccc12

InChI Key InChIKey=FPVHORFNDSKMPV-UHFFFAOYSA-N

Data  8 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 319609   

Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataEC50:  9.75nMAssay Description:The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataIC50: 5.43nMAssay Description:The D2 receptor antagonism activity test (The antagonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataIC50: 2.90nMAssay Description:The 5-HT2A receptor antagonism activity test (The antagonism activity of test compounds on 5-HT2A receptor expressing human recombinant 5-HT2A recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetAlpha-1A adrenergic receptor(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataIC50: 151nMAssay Description:Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at 5-HT2C receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataEC50:  9.80nMAssay Description:Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at dopamine D2 receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataIC50: 177nMAssay Description:Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataIC50: 2.90nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Xinjiang Technical Institute of Physics and Chemistry

Curated by ChEMBL
LigandPNGBDBM319609(US10174011, Example 4 | 3-(2-(4-(benzo[b]thiophen-...)
Affinity DataIC50: 4.05E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed