BDBM319565 1-(((4R,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4-yl)methoxy)-7-isopropoxyisoquinoline-6-carboxamide::US10174000, Example 16

SMILES CC(C)Oc1cc2c(OC[C@@H]3NC(=O)[C@@H](F)C33CC3)nccc2cc1C(N)=O

InChI Key InChIKey=XIQIABFZTSHPQF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 319565   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandPNGBDBM319565(1-(((4R,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Affinity DataIC50: 4.50E+3nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Pfizer

US Patent
LigandPNGBDBM319565(1-(((4R,7S)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4...)
Affinity DataIC50: 390nMAssay Description:This is an in vitro assay to measure IRAK4 enzymatic activity utilizing the DELFIA (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay, Perkin-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent