BDBM318940 US10173988, Compound inventive

SMILES Cc1ccc(cc1)N1CCN(Cc2nc(N)nc(Nc3ccc(C)c(C)c3)n2)CC1

InChI Key InChIKey=BZFYMFCKLUAOET-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 318940   

TargetNADPH oxidase 1(Human)
Glucox Biotech

US Patent
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 6.60E+4nMAssay Description:CHO cells modified to stably express human Nox1 were grown in DMEM/F12 gibco 31331 containing 10% FBS and 1% pen/strep at 37° C. in air with 5% CO2. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
Glucox Biotech

US Patent
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 1.60E+4nMAssay Description:Cells: Human blood was purchased in buffy coat, prepared the same day for isolation of neutrophils, from Labjoy AB, Lund, Sweden. Blood components we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetNADPH oxidase 4(Human)
Glucox Biotech

US Patent
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 670nMAssay Description:Cells: HEK (CJ Nox4) stably expressing Nox4 was purchased from Redoxis AB (Lund). The adherent cells were cultivated in RPMI 1640 with L-Glutamine we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetCytochrome b-245 heavy chain(Human)
Glucox Biotech

US Patent
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of NOX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
Glucox Biotech

US Patent
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of NOX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NOX3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
Glucox Biotech

US Patent
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 680nMAssay Description:Inhibition of NOX4 ( unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 570nMAssay Description:Inhibition of NOX5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed