BDBM318881 N-(2-methoxy-3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide::US10172868, Compound C063::US10653701, Compound C063::US11304957, Compound C063

SMILES COc1c(NC(=O)C=C)cccc1-c1cccc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12

InChI Key InChIKey=ZOGWNISXHPUMMP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318881   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Neupharma

US Patent
LigandPNGBDBM318881(US10172868, Compound C063 | N-(2-methoxy-3-(2-((4-...)
Affinity DataIC50: 100nMAssay Description:The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Neupharma

US Patent
LigandPNGBDBM318881(US10172868, Compound C063 | N-(2-methoxy-3-(2-((4-...)
Affinity DataIC50: 100nMAssay Description:(i) Peptide/Kinase Mixtures for measurement of EGFR (ErbB1):The 2×EGFR (ErbB1)/Tyr 04 mixture is prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/31/2021
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Neupharma

US Patent
LigandPNGBDBM318881(US10172868, Compound C063 | N-(2-methoxy-3-(2-((4-...)
Affinity DataIC50: 100nMAssay Description:EGFR (T790M)(L858R):The 2×EGFR (ErbB1) T790M L858R/Tyr 04 mixture is prepared in 50 mM HEPES pH 6.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, 0.02% NaN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2022
Entry Details
Go to US Patent