BDBM31810 Apogossypol derivative, 8r

SMILES CC(CNC(=O)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(=O)NCC(C)c3ccccc3)c(O)c(O)cc2c1O)c1ccccc1

InChI Key InChIKey=RAYNZUHYMMLQQA-UHFFFAOYSA-N

Data  12 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 31810   

TargetBcl-2-like protein 1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 760nM Kd:  110nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 320nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 280nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 730nMT: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 330nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Mcl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 420nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bfl-1 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 660nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 390nMAssay Description:Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 620nMAssay Description:Inhibition of Bfl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 310nMAssay Description:Inhibition of Bcl-xl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 320nMAssay Description:Inhibition of Bcl-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 200nMAssay Description:Inhibition of Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed