BDBM318038 2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-yl]-8-methyl-3,5,6,7-tetrahydropyrido [2,3-d]pyrimidin-4-one::US9624218, Example 39

SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cn2)CC1

InChI Key InChIKey=WTVLTJMRTHFMJP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318038   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Eli Lilly

US Patent
LigandPNGBDBM318038(2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...)
Affinity DataIC50: 30.3nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Eli Lilly

US Patent
LigandPNGBDBM318038(2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...)
Affinity DataIC50: 15.9nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM318038(2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...)
Affinity DataIC50: 7.74E+3nMAssay Description:The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent