BDBM318030 8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5,6,7-tetrahydropyrido[2,3- d]pyrimidin-4-one dihydrochloride::US9624218, Example 31

SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C)CC1

InChI Key InChIKey=WZAAURATTBNWBC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318030   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Eli Lilly

US Patent
LigandPNGBDBM318030(8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...)
Affinity DataIC50: 15.2nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Eli Lilly

US Patent
LigandPNGBDBM318030(8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...)
Affinity DataIC50: 12.2nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM318030(8-Methyl-2-[4-(o- tolylmethyl)piperazin-1-yl]- 3,5...)
Affinity DataIC50: 1.74E+4nMAssay Description:The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent