BDBM31802 Apogossypol::US9115061, Apogossypol

SMILES CC(C)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)cc2c1O

InChI Key InChIKey=PBJKWGWHZVXBGU-UHFFFAOYSA-N

Data  4 KI  5 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 31802   

TargetBcl-2-like protein 1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50: 3.70E+3nM Kd:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50: 4.30E+3nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50: 2.60E+3nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetBcl-2-related protein A1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50: 3.69E+3nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes) and purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataKd:  1.70E+3nMpH: 7.4Assay Description:Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataEC50:  2.80E+3nMAssay Description:Inhibition of Flu-BakBH3 binding to GST-tagged Bcl-2 (unknown origin) preincubated for 10 mins followed by Flu-BakBH3 addition and measured after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataKi:  640nMAssay Description:Inhibition of Bcl2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 2(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of Bcl-w (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of Bcl-xL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataKi:  3.35E+3nMAssay Description:Inhibition of MCl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed