BDBM318017 8-Methyl-2-[4-(1-pyrimidin-2-ylpropyl)piperazin-1-yl]-3,5,6,7-tetrahydropyrido[2,3-d]pyrimidin-4-one, Isomer 1::US9624218, Example 11::US9624218, Example 12

SMILES CCC(N1CCN(CC1)c1nc2N(C)CCCc2c(=O)[nH]1)c1ncccn1

InChI Key InChIKey=MMVLLPFESXFQML-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 318017   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Eli Lilly

US Patent
LigandPNGBDBM318017(US9624218, Example 11 | US9624218, Example 12 | 8-...)
Affinity DataIC50: 32.7nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Eli Lilly

US Patent
LigandPNGBDBM318017(US9624218, Example 11 | US9624218, Example 12 | 8-...)
Affinity DataIC50: 24.7nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Eli Lilly

US Patent
LigandPNGBDBM318017(US9624218, Example 11 | US9624218, Example 12 | 8-...)
Affinity DataIC50: 27.5nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Eli Lilly

US Patent
LigandPNGBDBM318017(US9624218, Example 11 | US9624218, Example 12 | 8-...)
Affinity DataIC50: 22nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM318017(US9624218, Example 11 | US9624218, Example 12 | 8-...)
Affinity DataIC50: 1.35E+4nMAssay Description:The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM318017(US9624218, Example 11 | US9624218, Example 12 | 8-...)
Affinity DataIC50: 5.05E+3nMAssay Description:The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent