BDBM31778 thieno[2,3-d]pyrimidine deriv., 2a

SMILES CCc1sc2nc(N)[nH]c(=O)c2c1Sc1ccccc1

InChI Key InChIKey=QZOQZFJSAYISAP-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 31778   

TargetThymidylate synthase(Human)
Duquesne University

LigandPNGBDBM31778(thieno[2,3-d]pyrimidine deriv., 2a)
Affinity DataIC50: 5.60E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed
TargetThymidylate synthase(Escherichia coli (strain K12))
Duquesne University

LigandPNGBDBM31778(thieno[2,3-d]pyrimidine deriv., 2a)
Affinity DataIC50: 2.80E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM31778(thieno[2,3-d]pyrimidine deriv., 2a)
Affinity DataIC50: 8.40E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

LigandPNGBDBM31778(thieno[2,3-d]pyrimidine deriv., 2a)
Affinity DataIC50: 2.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli (strain K12))
Duquesne University

LigandPNGBDBM31778(thieno[2,3-d]pyrimidine deriv., 2a)
Affinity DataIC50: 3.30E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM31778(thieno[2,3-d]pyrimidine deriv., 2a)
Affinity DataIC50: 33nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM31778(thieno[2,3-d]pyrimidine deriv., 2a)
Affinity DataIC50: 33nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed