BDBM317640 (R)-5-hydroxy-5-(5-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)thiazol-2-yl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid ::US9624210, Example 1B (R-enantiomer)

SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)[C@@]1(O)CCCc2cc(ccc12)C(O)=O

InChI Key InChIKey=HUWSYHXJLSHRDI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 317640   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317640(US9624210, Example 1B (R-enantiomer) | (R)-5-hydr...)
Affinity DataIC50: 0.508nMAssay Description:A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
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