BDBM317452 US9617250, S-entiomer of Example 22 of D1

SMILES CCc1cc(cc(C)c1OC[C@@H](O)CNC(=O)CO)-c1noc(n1)-c1cc(C)nc(CC(C)C)c1

InChI Key InChIKey=XUUJHESXLQZPNS-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 317452   

TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM317452(US9617250, S-entiomer of Example 22 of D1)
Affinity DataEC50:  0.100nMAssay Description:GTPγS binding assays are performed in 96 well microtiter plates (Nunc, 442587) in a final volume of 200 μl, using membrane preparations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM317452(US9617250, S-entiomer of Example 22 of D1)
Affinity DataEC50:  33nMAssay Description:GTPγS binding assays are performed in 96 well microtiter plates (Nunc, 442587) in a final volume of 200 μl, using membrane preparations of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM317452(US9617250, S-entiomer of Example 22 of D1)
Affinity DataEC50:  33nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells incubated for 30 mins prior to [35S]-GTPgammaS addition measured after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM317452(US9617250, S-entiomer of Example 22 of D1)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in CHO cells incubated for 30 mins prior to [35S]-GTPgammaS addition measured after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed