BDBM31587 oxadiazole derivative, 20x

SMILES COc1ccc(cc1)-n1cnc2ccc(cc12)-c1nnc(SCc2cccc(c2)C#N)o1

InChI Key InChIKey=XUEHEOHRTKKVET-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 31587   

TargetGlycogen synthase kinase-3 beta(Human)
Takeda Pharmaceutical

LigandPNGBDBM31587(oxadiazole derivative, 20x)
Affinity DataIC50: 2.30nMpH: 7.5 T: 2°CAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Takeda Pharmaceutical

LigandPNGBDBM31587(oxadiazole derivative, 20x)
Affinity DataIC50: 1.00E+4nMAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Takeda Pharmaceutical

LigandPNGBDBM31587(oxadiazole derivative, 20x)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Human p35/ cyclin dependent kinase 5 (CDK5) was purchased from Millipore Corp. (Bedford, MA), which was expressed as N-terminal GST fusion protein us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
LigandPNGBDBM31587(oxadiazole derivative, 20x)
Affinity DataIC50: 4.60E+3nMAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 1(Human)
Takeda Pharmaceutical

LigandPNGBDBM31587(oxadiazole derivative, 20x)
Affinity DataIC50: 8.10E+3nMAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetProtein kinase C theta type(Human)
Takeda Pharmaceutical

LigandPNGBDBM31587(oxadiazole derivative, 20x)
Affinity DataIC50: 3.50E+3nMAssay Description:Human GSK-3beta was expressed as the N-terminal FLAG-tagged protein using a baculovirus expression system. The kinase assay was was conducted in a 96...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed