BDBM315816 US10172851, Example 459

SMILES COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OC3CC(O)C3)cn3ncc(C#N)c23)cn1

InChI Key InChIKey=AKJKXOKUFCDFCO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 315816   

LigandPNGBDBM315816(US10172851, Example 459)
Affinity DataIC50: 10.6nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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LigandPNGBDBM315816(US10172851, Example 459)
Affinity DataIC50: 56.1nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM315816(US10172851, Example 459)
Affinity DataIC50: 123nMAssay Description:The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent