BDBM315616 (3-Chloro-pyridin-2-yl)- [4-fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)phenyl]- methanol1H NMR (500 MHz, DMSO-d6) ppm = 9.09 (s, 1H), 8.56 (dd, J = 4.6, 1.4, 1H), 7.92 (dd, J = 8.1, 1.4, 1H), 7.64-7.59 (m, 2H), 7.54-7.49 (m, 2H), 7.40- 7.34 (m, 2H), 7.22-7.17 (m, 1H), 6.21 (s, 1H), 6.18-6.09 (m, 1H), 3.81-3.73 (m, 4H), 3.48- 3.40 (m, 4H)::US10172859, Example 42::US10172859, Example 465::US10172859, Example 466::US11065253, Example 42::US9732094, Example 466

SMILES OC(c1ccc(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1)c1ncccc1Cl

InChI Key InChIKey=IKPAUHLVUSUQBQ-UHFFFAOYSA-N

Data  6 KI  9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 315616   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataIC50: 18.5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataIC50: 19nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataIC50: 18.5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315616(US10172859, Example 465 | US10172859, Example 466 ...)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL