BDBM315509 US10172858, Table 2.5::US10544104, Compound 27::US11247972, Compound 27::US9765037, Compound 27::US9828378, # 5

SMILES COc1ccc2[nH]c(cc2c1)-c1nn(C(C)C)c2ncnc(N)c12

InChI Key InChIKey=KGLWFPORHQPXJI-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 315509   

TargetSerine/threonine-protein kinase mTOR(Human)
Intellikine

US Patent
LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 500nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 500nMAssay Description:This assay is relatively simple, reasonably sensitive, and the peptide substrate can be adjusted both in terms of sequence and concentration to meet ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 56.9nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 623nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
Go to US Patent

TargetCytosolic arginine sensor for mTORC1 subunit 1(Human)
Intellikine

US Patent
LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 500nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110 /p85α from Upstate, and p110γ from Sigma) or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
Go to US Patent

LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 500nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110 /p85α from Upstate, and p110γ from Sigma) or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2019
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 56.9nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For

US Patent
LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 623nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
Go to US Patent

TargetcGMP-dependent protein kinase(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 56.9nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent

TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM315509(US10172858, Table 2.5 | US9765037, Compound 27 | U...)
Affinity DataIC50: 623nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent