BDBM314833 (−) (R) 3-[3-({[4-(5-Chloropyridin-3-yl)phenyl](cyclopentyl)acetyl}amino)-2-methylphenyl]propanoic acid::US10172814, Example 17

SMILES Cc1c(CCC(O)=O)cccc1NC(=O)[C@H](C1CCCC1)c1ccc(cc1)-c1cncc(Cl)c1

InChI Key InChIKey=LUWOXMQWGOWQSN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 314833   

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM314833( (−) (R) 3-[3-({[4-(5-Chloropyridin-3-yl)phe...)
Affinity DataIC50: 35nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM314833( (−) (R) 3-[3-({[4-(5-Chloropyridin-3-yl)phe...)
Affinity DataIC50: 35.2nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProstaglandin E synthase(Mouse)
Bayer

Curated by ChEMBL
LigandPNGBDBM314833( (−) (R) 3-[3-({[4-(5-Chloropyridin-3-yl)phe...)
Affinity DataIC50: 765nMAssay Description:Inhibition of mouse recombinant FLAG-tagged PTGES expressed in baculovirus infected Hi-5 insect cells using prostaglandin H2 as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM314833( (−) (R) 3-[3-({[4-(5-Chloropyridin-3-yl)phe...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant FLAG-tagged PTGES expressed in baculovirus infected Hi-5 insect cells using prostaglandin H2 as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed